Design, Synthesis and Antimicrobial Evaluation of Some Novel Quinoline Derivatives
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چکیده
The Global Burden of Disease Study(GBDS) estimates that infectious diseases were responsible for 22% of all deaths and 27% of disability-adjusted life years (DALYS ) worldwide according to WHO [1]. Antimicrobial resistance among clinically important bacteria is widely acknowledged as a major global public health threat [2]. Most of the currently used antimicrobial drugs are associated with adverse effects, such as hepatotoxicity and hypersensitivity [3,4]. The widespread distribution of infectious diseases, the presence of antimicrobial resistance and the increased side effect of the antimicrobial drugs enhance temptation to design new more effective, safe and economic drugs to treat such infectious diseases and make the field of antimicrobial drug discovery to be of high priority.
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